APC is a tumor suppressor which has a crucial role in down-regulating Wnt signaling. Our lab studies different aspects of APC expression, mainly its role in the early stages of CRC development.

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An emerging method for studying the colon is the organoid system.  Colonic organoids are 3-dimensional structures that resemble the full organ in microstructures, cell types and growth characteristics and thus serves as a reliable model for therapeutic intervention.

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We grow colon organoids from human normal and CRC biopsies. These colonoides are analyzed and are currently cultivated in order to establish novel treatment strategies.